GATA6 antibody (AA 26-296)

Catalog No. ABIN7872994

The Rabbit Polyclonal anti-GATA6 antibody (ABIN7872994) specifically detects GATA6 in IHC (p). The antibody is reactive with Zebrafish (Danio rerio) samples.

Quick Overview for GATA6 antibody (AA 26-296) (ABIN7872994)

Target: GATA6 (GATA Binding Protein 6 (GATA6))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GATA6 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GATA6 Antibody

Binding Specificity: AA 26-296

Purpose: Zebrafish Gata6 Antibody / GATA-binding factor 6

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Gata6 recombinant protein (amino acids E26-E296) was used as the immunogen for the Zebrafish Gata6 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Gata6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Gata6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for GATA6

Target: GATA6 (GATA Binding Protein 6 (GATA6))

Alternative Name: Gata6

Background: GATA-binding protein 6 (Gata6) is a zinc finger transcription factor belonging to the GATA family, which regulates gene expression during embryonic development and cell lineage specification. In zebrafish (Danio rerio), Gata6 plays a key role in the development of the endoderm, heart, and gut, as well as in organ morphogenesis and tissue differentiation.

During early zebrafish embryogenesis, Gata6 is expressed in the endodermal and mesodermal layers, where it works in concert with Gata4 and Gata5 to specify endodermal fate and initiate the morphogenesis of organs such as the liver, pancreas, and intestine. It also contributes to cardiac progenitor specification and the formation of the heart tube, making it essential for proper cardiovascular development.

Due to its high conservation and central role in organogenesis, zebrafish Gata6 is widely used as a model to study developmental gene regulation, cardiogenesis, and congenital diseases affecting the heart and gastrointestinal tract. It is also a valuable marker for analyzing endodermal derivatives and early tissue patterning in vertebrate embryos.

UniProt: Q6NW63