PDCD1LG2 antibody (AA 27-220)

Catalog No. ABIN7873097

This Mouse Monoclonal antibody specifically detects PDCD1LG2 in FACS. It exhibits reactivity toward Human.

Quick Overview for PDCD1LG2 antibody (AA 27-220) (ABIN7873097)

Target: PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PDCD1LG2 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: PDL2-1850

Product Details anti-PDCD1LG2 Antibody

Binding Specificity: AA 27-220

Purpose: PDL2 Antibody / Programmed death ligand 2 / CD273

Purification: Protein G affinity chromatography

Immunogen: A recombinant fragment of human PD-L2 protein within amino acids 27-220 was used as the immunogen for the PDL2 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the PDL2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the PDL2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for PDCD1LG2

Target: PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))

Alternative Name: PDL2

Background: Recognizes a protein of about 31 kDa, which is identified as PD-L2 (same as PDCD1LG2). Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. PD-L2 does not bind CD28, cytotoxic T lymphocyte A4 or ICOS (inducible co-stimulator). The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.