BMP4 antibody (AA 27-279)

Catalog No. ABIN7873109

This Rabbit Polyclonal antibody specifically detects BMP4 in WB and IHC (p). It exhibits reactivity toward Zebrafish (Danio rerio).

Quick Overview for BMP4 antibody (AA 27-279) (ABIN7873109)

Target: BMP4 (Bone Morphogenetic Protein 4 (BMP4))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMP4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-BMP4 Antibody

Binding Specificity: AA 27-279

Purpose: Zebrafish Bmp2b Antibody / Bone morphogenetic protein 2

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Bmp2b recombinant protein (amino acids E27-D279) was used as the immunogen for the Zebrafish Bmp2b antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Bmp2b antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Bmp2b antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for BMP4

Target: BMP4 (Bone Morphogenetic Protein 4 (BMP4))

Alternative Name: Bmp2b

Background: Bone morphogenetic protein 2b (Bmp2b) is a secreted signaling molecule belonging to the transforming growth factor-beta (TGF-beta) superfamily, and it plays a pivotal role in embryonic development, cell fate specification, and morphogenesis. In zebrafish (Danio rerio), Bmp2b is an essential factor in dorsoventral patterning, organogenesis, and skeletal development.

During early embryogenesis, bmp2b is expressed in ventral tissues and functions as a key morphogen that establishes dorsoventral polarity by forming a signaling gradient. Loss-of-function mutations in bmp2b, such as the well-known swirl mutant, result in dorsalized embryos, underscoring its essential role in ventral tissue specification. Bmp2b also regulates the development of multiple organ systems, including the heart, fins, and skeletal elements, through its influence on proliferation, differentiation, and apoptosis of progenitor cells.

Zebrafish Bmp2b is widely studied as a model for developmental signaling, stem cell biology, and tissue regeneration. It also provides a powerful system for investigating TGF-beta pathway modulation, signal transduction, and congenital malformations resulting from disrupted BMP signaling.

UniProt: O93369

Pathways: Steroid Hormone Mediated Signaling Pathway, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development