Mesothelin antibody (AA 273-407)

Catalog No. ABIN7873175

This Mouse Monoclonal antibody specifically detects Mesothelin in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Mesothelin antibody (AA 273-407) (ABIN7873175)

Target: Mesothelin (MSLN)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Mesothelin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MSLN-3385

Product Details anti-Mesothelin Antibody

Binding Specificity: AA 273-407

Purpose: Mesothelin Antibody / MSLN

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 273-407 from the human protein was used as the immunogen for the Mesothelin antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the Mesothelin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Mesothelin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Mesothelin

Target: Mesothelin (MSLN)

Alternative Name: Mesothelin

Background: Mesothelin is a 40 kDa glycosyl-phosphatidylinositol-anchored glycoprotein cleaved from a 69 kDa precursor protein. Mesothelin immunoreactivity is high in cancers of the ovary (serous papillary, endometrioid and undifferentiated) and pancreas, with less frequent staining seen in adenocarcinomas of the endometrium, lung and stomach/esophagus. Mesothelin is one of the most sensitive markers for mesothelioma.

UniProt: Q13421

Pathways: EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process