Mesothelin antibody (AA 273-407)

Catalog No. ABIN7873191

The Mouse Monoclonal anti-Mesothelin antibody is suitable to detect Mesothelin in samples from Human, Mouse and Rat. It has been validated for IHC (p).

Quick Overview for Mesothelin antibody (AA 273-407) (ABIN7873191)

Target: Mesothelin (MSLN)

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Mesothelin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MKPF-1

Product Details anti-Mesothelin Antibody

Binding Specificity: AA 273-407

Purpose: MSLN Antibody / Mesothelin

Purification: Protein G affinity

Immunogen: A portion of amino acids 273-407 from the human protein was used as the immunogen for this MSLN antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the MSLN antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MSLN antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Mesothelin

Target: Mesothelin (MSLN)

Alternative Name: MSLN

Background: Mesothelin is a 40 kDa glycosyl-phosphatidylinositol-anchored glycoprotein cleaved from a 69 kDa precursor protein. Mesothelin immunoreactivity is high in cancers of the ovary (serous papillary, endometrioid and undifferentiated) and pancreas, with less frequent staining seen in adenocarcinomas of the endometrium, lung and stomach/esophagus. Mesothelin is one of the most sensitive markers for mesothelioma.

UniProt: Q13421

Pathways: EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process