Mesothelin antibody (AA 273-407) (Biotin)

Catalog No. ABIN7873193

This Mouse Monoclonal antibody specifically detects Mesothelin in IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Mesothelin antibody (AA 273-407) (Biotin) (ABIN7873193)

Target: Mesothelin (MSLN)

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Mesothelin antibody is conjugated to Biotin

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MSLN-2131

Product Details anti-Mesothelin Antibody (Biotin)

Binding Specificity: AA 273-407

Purpose: Mesothelin Antibody / MSLN

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 273-407 from the human protein was used as the immunogen for the Mesothelin antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the Mesothelin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 mg/mL with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Mesothelin antibody at 2-8oC (up to one month) or aliquot and store at -20oC (longer term).

Target Details for Mesothelin

Target: Mesothelin (MSLN)

Alternative Name: Mesothelin

Background: Mesothelin is a 40 kDa glycosyl-phosphatidylinositol-anchored glycoprotein cleaved from a 69 kDa precursor protein. Mesothelin immunoreactivity is high in cancers of the ovary (serous papillary, endometrioid and undifferentiated) and pancreas, with less frequent staining seen in adenocarcinomas of the endometrium, lung and stomach/esophagus. Mesothelin is one of the most sensitive markers for mesothelioma.

UniProt: Q13421

Pathways: EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process