SLC22A6 antibody (AA 286-563)

Catalog No. ABIN7873319

This Rabbit Polyclonal antibody specifically detects SLC22A6 in WB, ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for SLC22A6 antibody (AA 286-563) (ABIN7873319)

Target: SLC22A6 (Solute Carrier Family 22 Member 6 (SLC22A6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC22A6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-SLC22A6 Antibody

Binding Specificity: AA 286-563

Purpose: OAT1 Antibody / Organic anion transporter 1 / SLC22A6

Immunogen: E.coli-derived human OAT1/SLC22A6 recombinant protein (Position: R286-L563) was used as the immunogen for the OAT1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the OAT1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the OAT1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SLC22A6

Target: SLC22A6 (Solute Carrier Family 22 Member 6 (SLC22A6))

Alternative Name: OAT1

Background: OAT1 antibody detects Organic anion transporter 1, a renal membrane transporter responsible for the uptake of a wide range of endogenous metabolites and xenobiotics. OAT1 plays a vital role in drug excretion, toxin clearance, and metabolic waste handling. The OAT1 antibody is used in nephrology, pharmacology, and toxicology research to study renal secretion, drug-drug interactions, and kidney function.

OAT1 is encoded by the SLC22A6 gene located on human chromosome 11q12.3. The protein is approximately 563 amino acids long and belongs to the solute carrier 22 family. OAT1 is expressed predominantly in the basolateral membrane of renal proximal tubule cells, where it mediates the uptake of organic anions from the bloodstream into tubular cells, enabling their secretion into urine via apical transporters.

The OAT1 antibody detects a 60 kilodalton band by western blot and shows basolateral membrane staining in kidney tissue sections. OAT1 transports metabolites such as urate, prostaglandins, and p-aminohippurate, as well as drugs including antivirals, diuretics, and antibiotics. Its activity depends on the transmembrane exchange of alpha-ketoglutarate, coupling organic anion uptake to cellular metabolism.

Because OAT1 handles many pharmaceuticals, it is a major determinant of drug pharmacokinetics and toxicity. Inhibition or saturation of OAT1 can lead to altered drug clearance and nephrotoxicity. Genetic polymorphisms in OAT1 affect drug response variability and susceptibility to renal injury. Beyond renal physiology, OAT1 contributes to organic acid homeostasis in the brain and choroid plexus.

By regulating solute movement between blood and urine, OAT1 maintains chemical balance and metabolic detoxification. NSJ Bioreagents provides a validated OAT1 antibody optimized for its applications, supporting research into kidney physiology, drug metabolism, and transporter-mediated toxicity.

UniProt: Q4U2R8

Pathways: Dicarboxylic Acid Transport