Gephyrin antibody (AA 288-735)

Catalog No. ABIN7873329

The Rabbit Polyclonal anti-Gephyrin antibody is suitable to detect Gephyrin in samples from Zebrafish (Danio rerio). It has been validated for WB and IHC (p).

Quick Overview for Gephyrin antibody (AA 288-735) (ABIN7873329)

Target: Gephyrin (GPHN)

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Gephyrin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Gephyrin Antibody

Binding Specificity: AA 288-735

Purpose: Zebrafish Gephyrin Antibody / Gphna / Gphnb

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived zebrafish GPHNa/b recombinant protein (amino acids V288-L735) was used as the immunogen for the Zebrafish Gephyrin antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Gephyrin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Gephyrin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Gephyrin

Target: Gephyrin (GPHN)

Alternative Name: Gephyrin

Background: Gephyrin is a protein that in humans is encoded by the GPHN gene. This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described, however, the full-length nature of all transcript variants is not currently known.

UniProt: D3KYK7

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development