GSTA4 antibody (AA 29-222)

Catalog No. ABIN7873400

This Rabbit Polyclonal antibody specifically detects GSTA4 in WB, ELISA, FACS and IHC (p). It exhibits reactivity toward Human and Monkey.

Quick Overview for GSTA4 antibody (AA 29-222) (ABIN7873400)

Target: GSTA4 (Glutathione S-Transferase alpha 4 (GSTA4))

Reactivity: Human, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GSTA4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GSTA4 Antibody

Binding Specificity: AA 29-222

Purpose: GSTA4 Antibody

Purification: Affinity purified

Immunogen: A human recombinant partial protein (amino acids E29-P222) was used as the immunogen for the GSTA4 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GSTA4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the GSTA4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for GSTA4

Target: GSTA4 (Glutathione S-Transferase alpha 4 (GSTA4))

Alternative Name: GSTA4

Background: Glutathione S-transferase A4, also known as GSTA4, is an enzyme which in humans is encoded by the GSTA4 gene. Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver (hepatocytes) and kidney (proximal tubules). In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity, thereby protecting the cells from reactive oxygen species and the products of peroxidation.

UniProt: O15217