MFAP3L antibody (AA 29-409)

Catalog No. ABIN7873420

The Rabbit Polyclonal anti-MFAP3L antibody (ABIN7873420) specifically detects MFAP3L in ELISA, WB, IF and ICC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for MFAP3L antibody (AA 29-409) (ABIN7873420)

Target: MFAP3L (Microfibrillar-Associated Protein 3-Like (MFAP3L))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MFAP3L antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-MFAP3L Antibody

Binding Specificity: AA 29-409

Purpose: MFAP3L Antibody / Microfibril-associated protein 3-like

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human MFAP3L recombinant protein (Position: K29-V409) was used as the immunogen for the MFAP3L antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MFAP3L antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MFAP3L antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MFAP3L

Target: MFAP3L (Microfibrillar-Associated Protein 3-Like (MFAP3L))

Alternative Name: MFAP3L

Background: MFAP3L antibody detects Microfibril-associated protein 3-like, a cytoplasmic adaptor protein involved in cell signaling, cytoskeletal regulation, and extracellular matrix organization. The UniProt recommended name is Microfibril-associated protein 3-like (MFAP3L). Although its precise function remains under study, MFAP3L has been implicated in modulating cell adhesion and motility through protein-protein interactions within signaling networks.

Functionally, MFAP3L antibody identifies a 386-amino-acid cytoplasmic protein that associates with signaling molecules such as small GTPases, actin-binding proteins, and scaffolding complexes. MFAP3L contributes to cytoskeletal organization and may facilitate communication between extracellular matrix components and intracellular signaling pathways. Its expression has been linked to the regulation of cell migration, proliferation, and differentiation.

The MFAP3L gene is located on chromosome 4q32.1 and encodes a protein expressed in diverse tissues, including heart, lung, and skeletal muscle. MFAP3L shares sequence similarity with other microfibril-associated proteins but lacks classical extracellular matrix domains, suggesting a distinct intracellular regulatory role. It has been proposed to interact with Rho family GTPases and participate in actin cytoskeleton remodeling during cell movement and adhesion.

In cancer biology, elevated MFAP3L expression has been observed in certain epithelial tumors, including breast and colorectal cancer, where it may contribute to increased motility and invasive potential. Conversely, in cardiac and skeletal muscle, MFAP3L may assist in maintaining structural stability under mechanical stress. Although its specific mechanisms remain to be fully elucidated, MFAP3L appears to function at the interface of cytoskeletal dynamics and signal transduction.

MFAP3L antibody is widely used in cell biology, oncology, and signal transduction research. It is suitable for immunoblotting, immunofluorescence, and co-immunoprecipitation to study MFAP3L localization and binding partners. This antibody supports research into cytoskeletal control, extracellular matrix signaling, and tumor progression. In developmental studies, MFAP3L serves as a marker of cytoplasmic microfibril-associated proteins involved in tissue structure and mechanical adaptation.

Structurally, MFAP3L contains multiple coiled-coil regions that promote protein complex formation and interaction with cytoskeletal regulators. Its expression may be modulated by growth factor signaling and mechanical cues. NSJ Bioreagents provides MFAP3L antibody reagents validated for use in cytoskeletal organization, signaling regulation, and cancer research.

UniProt: O75121