Integrin beta 4 antibody (AA 29-431)

Catalog No. ABIN7873421

This Mouse Monoclonal antibody specifically detects Integrin beta 4 in WB, FACS and IF. It exhibits reactivity toward Human.

Quick Overview for Integrin beta 4 antibody (AA 29-431) (ABIN7873421)

Target: Integrin beta 4 (ITGB4)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Integrin beta 4 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: 7G10D2

Product Details anti-Integrin beta 4 Antibody

Binding Specificity: AA 29-431

Purpose: Integrin beta 4 Antibody / ITGB4 / CD104

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids R29-K431) was used as the immunogen for the Integrin beta 4 antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the Integrin beta 4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Integrin beta 4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Integrin beta 4

Target: Integrin beta 4 (ITGB4)

Alternative Name: Integrin beta 4

Background: ITGB4 (Integrin, beta-4), also known as CD104 (Cluster of Differentiation 104), is a human gene. The gene encodes the integrin beta 4 subunits, a receptor for the laminins. This subunit tends to associate with alpha 6 subunits and is likely to play a pivotal role in the biology of invasive carcinoma. The ITGB4 gene is mapped on 17q25.1. Using expression profiling, Yang et al. found that ITGB4 was upregulated 6-fold by ZKSCAN3 in transfected human colon cancer cells compared with parental cells. They confirmed that ZKSCAN3 bound the promoter of ITGB4 in vitro and in vivo. ITGB4 knockdown by short hairpin RNA countered ZKSCAN3-augmented anchorage-independent colony formation in the colon cancer cell lines. The integrin beta-4 subunit is characterized by an unusually long cytoplasmic domain that harbors 4 fibronectin type III (FNIII) repeats, residing in 2 pairs separated by a connecting segment. Vidal et al. found compound heterozygosity for mutations in the ITGB4 gene in an infant with junctional epidermolysis bullosa associated with pyloric atresia.

UniProt: P16144

Pathways: Integrin Complex