CD276 antibody (AA 7-3, AA 29-458)

Catalog No. ABIN7873425

The Rabbit Polyclonal anti-CD276 antibody is suitable to detect CD276 in samples from Human. It has been validated for WB, ELISA, FACS and IHC (p).

Quick Overview for CD276 antibody (AA 7-3, AA 29-458) (ABIN7873425)

Target: CD276

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD276 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CD276 Antibody

Binding Specificity: AA 7-3, AA 29-458

Purpose: B7-H3 Antibody / CD276

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids L29-Q458) was used as the immunogen for the B7-H3 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the B7-H3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the B7-H3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CD276

Target: CD276

Alternative Name: B7-H3

Background: Cluster of Differentiation 276 (CD276) or B7 Homolog 3 (B7-H3) is a human protein encoded by the CD276 gene. The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints