NCOA2 antibody (AA 297-1071)

Catalog No. ABIN7873467

The Rabbit Polyclonal anti-NCOA2 antibody is suitable to detect NCOA2 in samples from Human. It has been validated for WB, IHC, ELISA, IF, ICC and FACS.

Quick Overview for NCOA2 antibody (AA 297-1071) (ABIN7873467)

Target: NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCOA2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Product Details anti-NCOA2 Antibody

Binding Specificity: AA 297-1071

Purpose: NCOA2 Antibody / Nuclear receptor coactivator 2

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human NCOA2 recombinant protein (Position: E297-E1071) was used as the immunogen for the NCOA2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the NCOA2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the NCOA2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for NCOA2

Target: NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))

Alternative Name: NCOA2

Background: NCOA2 antibody detects Nuclear receptor coactivator 2, encoded by the NCOA2 gene. Nuclear receptor coactivator 2 is a transcriptional coactivator that interacts with nuclear hormone receptors and enhances their transcriptional activity. NCOA2 antibody provides researchers with a valuable reagent for studying gene regulation, endocrine signaling, and cancer biology.

Nuclear receptor coactivator 2, also called SRC2 or GRIP1, belongs to the p160 family of coactivators. Research using NCOA2 antibody has shown that it interacts with estrogen receptor, glucocorticoid receptor, thyroid hormone receptor, and peroxisome proliferator-activated receptor. By recruiting histone acetyltransferases and chromatin remodeling complexes, NCOA2 promotes transcriptional activation in response to hormones and ligands.

Studies with NCOA2 antibody have revealed that it is widely expressed in endocrine tissues, brain, and muscle. Its ability to act as a transcriptional scaffold allows integration of multiple signaling inputs, fine-tuning transcriptional responses. This makes NCOA2 central to metabolism, reproduction, and development.

Dysregulation of NCOA2 has been linked to endocrine disorders and cancer. Research using NCOA2 antibody has shown that chromosomal translocations involving NCOA2 occur in acute lymphoblastic leukemia and mesenchymal tumors. Overexpression has also been observed in prostate and breast cancers, where NCOA2 enhances oncogenic signaling. These findings underscore its importance as a biomarker and potential therapeutic target.

NCOA2 antibody is widely used in chromatin immunoprecipitation, western blotting, and immunohistochemistry. Chromatin immunoprecipitation identifies nuclear receptor binding sites, western blotting quantifies coactivator expression, and immunohistochemistry demonstrates nuclear localization in hormone-responsive tissues. These methods make NCOA2 antibody essential for transcription and cancer research.

By providing validated NCOA2 antibody reagents, NSJ Bioreagents supports studies into transcriptional regulation, hormone signaling, and oncogenesis. Detection of Nuclear receptor coactivator 2 provides researchers with insight into how nuclear coactivators integrate signaling pathways and control gene expression.

UniProt: Q15596

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling