Calcitonin antibody (AA 3-116)

Catalog No. ABIN7873487

This Mouse Monoclonal antibody specifically detects Calcitonin in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Calcitonin antibody (AA 3-116) (ABIN7873487)

Target: Calcitonin (Calca)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Calcitonin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CALCA-3310

Product Details anti-Calcitonin Antibody

Binding Specificity: AA 3-116

Purpose: Calcitonin Antibody / CALCA / CGRP

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 3-116 was used as the immunogen for the Calcitonin antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the Calcitonin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Calcitonin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Calcitonin

Target: Calcitonin (Calca)

Alternative Name: Calcitonin

Background: Calcitonin is a hormone that preserves skeletal integrity and reduces blood calcium levels by decreasing osteoclast activity in bones, calcium and phosphate reabsorption by kidney tubules and calcium absorption by the intestines. The secretion of Calcitonin from the thyroid is regulated in part by estrogen, which increases Calcitonin mRNA levels. The Calcitonin gene, CALCA, undergoes tissue-specific RNA alternative splicing, resulting in the production of different mRNA transcripts. One transcript encodes procalcitonin as well as both calcium-lowering processed active polypeptides, Calcitonin and katacalcin. An alternative transcript of CALCA encodes the precursor for the neuropeptide referred to as Calcitonin generelated peptide 1, also designated CGRP1 or -CGRP. Mature CGRP1 and CGRP2 share significant sequence identity at the protein level differing by only 1-3 amino acid residues, depending on the species.

UniProt: P01258