SERBP1 antibody (AA 3-139)

Catalog No. ABIN7873493

This Mouse Monoclonal antibody specifically detects SERBP1 in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for SERBP1 antibody (AA 3-139) (ABIN7873493)

Target: SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SERBP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SERBP1-3494

Product Details anti-SERBP1 Antibody

Binding Specificity: AA 3-139

Purpose: SERBP1 Antibody / PAI-RBP1

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 3-139 from the human protein was used as the immunogen for the SERBP1 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the SERBP1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the SERBP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for SERBP1

Target: SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))

Alternative Name: SERBP1

Background: SERBP1 is a membrane-associated protein that localizes to the nucleus, the perinuclear region of the cytoplasm and the plasma membrane. It is believed to play a role in the regulation of mRNA stability, as it specifically binds to the CRS (cyclic nucleotide-responsive sequence) motif of the PAI-1 mRNA and acts to stabilize the mRNA and regulate its expression. In addition, SERBP1 interacts with Mi2-s antiapoptotic action in ovarian cell types. SERBP1 is overexpressed in ovarian cancer, suggesting a possible role in tumorigenesis and tumor metastasis.

UniProt: Q8NC51