SERBP1 antibody (AA 3-139)

Catalog No. ABIN7873504

The Mouse Monoclonal anti-SERBP1 antibody (Clone SERBP1-3497) (ABIN7873504) specifically detects SERBP1 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for SERBP1 antibody (AA 3-139) (ABIN7873504)

Target: SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SERBP1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SERBP1-3497

Product Details anti-SERBP1 Antibody

Binding Specificity: AA 3-139

Purpose: SERBP1 Antibody / PAI-RBP1

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein corresponding to amino acids 3-139 was used as the immunogen for the SERBP1 antibody.

Isotype: IgG2c, kappa

Application Details

Application Notes: Optimal dilution of the SERBP1 antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the SERBP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for SERBP1

Target: SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))

Alternative Name: SERBP1

Background: PAI-RBP1 (plasminogen activator inhibitor 1 RNA-binding protein), also known as SERBP1 (SERPINE1 mRNA-binding protein 1), CGI-55, CHD3IP (chromodomain helicase DNA binding protein 3 interacting protein), HABP4L or PAI-RBP1, is a membrane-associated protein that localizes to the nucleus, the perinuclear region of the cytoplasm and the plasma membrane. PAI-RBP1 is believed to play a role in the regulation of mRNA stability, as it specifically binds to the CRS (cyclic nucleotide-responsive sequence) motif of the PAI-1 mRNA and acts to stabilize the mRNA and regulate its expression. In addition, PAI-RBP1 interacts with Mi2-alpha and may be involved in chromatin remodeling. PAI-RBP1 also interacts with PGRMC1 and participates in the transduction of Progesterone's antiapoptotic action in ovarian cell types. The gene encoding PAI-RBP1 is overexpressed in ovarian cancer, suggesting a possible role for PAI-RBP1 in tumorigenesis and tumor metastasis.

UniProt: Q8NC51