BCR antibody (AA 3-264)

Catalog No. ABIN7873528

The Rabbit Polyclonal anti-BCR antibody (ABIN7873528) specifically detects BCR in WB, ELISA and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for BCR antibody (AA 3-264) (ABIN7873528)

Target: BCR (Breakpoint Cluster Region (BCR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCR antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-BCR Antibody

Binding Specificity: AA 3-264

Purpose: Breakpoint cluster region protein Antibody / BCR

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids D3-N264) was used as the immunogen for the Breakpoint cluster region protein antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Breakpoint cluster region protein antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Breakpoint cluster region protein antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for BCR

Target: BCR (Breakpoint Cluster Region (BCR))

Alternative Name: Breakpoint cluster region protein

Background: The breakpoint cluster region protein (BCR) is a protein that in humans is encoded by the BCR gene. A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

UniProt: P11274

Pathways: Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling