SRR antibody (AA 3-283)

Catalog No. ABIN7873531

The Rabbit Polyclonal anti-SRR antibody (ABIN7873531) specifically detects SRR in WB, IHC, ELISA, FACS, IF, IP and ICC. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for SRR antibody (AA 3-283) (ABIN7873531)

Target: SRR (Serine Racemase (SRR))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Product Details anti-SRR Antibody

Binding Specificity: AA 3-283

Purpose: Serine racemase Antibody / SRR

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human Serine racemase/SRR recombinant protein (Position: A3-E283) was used as the immunogen for the Serine racemase antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Serine racemase antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Serine racemase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SRR

Target: SRR (Serine Racemase (SRR))

Alternative Name: Serine racemase

Background: Serine racemase antibody detects Serine racemase, encoded by the SRR gene on chromosome 17p13.3. Serine racemase antibody is widely used in research on amino acid metabolism, neurotransmission, and neurodegeneration. Serine racemase is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the conversion of L-serine to D-serine, a co-agonist of NMDA receptors. This enzyme plays a central role in modulating glutamatergic neurotransmission and synaptic plasticity in the brain.

Structurally, Serine racemase is a ~37 kDa cytosolic protein containing a PLP-binding site and catalytic lysine essential for racemization activity. It forms homodimers, which stabilize enzymatic activity. In addition to racemization, Serine racemase can catalyze beta-elimination of water from serine to generate pyruvate, linking it to energy metabolism. Isoforms generated by alternative splicing display altered enzymatic properties.

Functionally, Serine racemase regulates D-serine availability, which acts at NMDA receptor glycine-binding sites to facilitate excitatory neurotransmission. This regulation influences synaptic plasticity, learning, and memory. Knockout studies demonstrate that loss of Serine racemase reduces D-serine levels, impairing NMDA receptor function. Researchers use Serine racemase antibody to study glutamatergic signaling, synaptic physiology, and neuropsychiatric disease.

Clinically, Serine racemase is implicated in schizophrenia, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and other neurological disorders. Reduced D-serine levels contribute to NMDA receptor hypofunction in schizophrenia, while elevated levels may cause excitotoxicity in ALS. Pharmacological modulation of Serine racemase activity is under investigation for treating these conditions. NSJ Bioreagents provides Serine racemase antibody for research in neurobiology, neurotransmission, and neurodegeneration.

Experimentally, Serine racemase antibody is used in western blotting to detect the ~37 kDa protein, in immunofluorescence microscopy to examine neuronal localization, and in immunohistochemistry to study brain distribution. Co-immunoprecipitation with Serine racemase antibody identifies interacting proteins such as GRIP and Golga3.

UniProt: Q9GZT4