GPX4 antibody (AA 30-197)

Catalog No. ABIN7873574

This Mouse Monoclonal antibody specifically detects GPX4 in WB. It exhibits reactivity toward Human.

Quick Overview for GPX4 antibody (AA 30-197) (ABIN7873574)

Target: GPX4 (Glutathione Peroxidase 4 (GPX4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GPX4 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 6I4E7

Product Details anti-GPX4 Antibody

Binding Specificity: AA 30-197

Purpose: Glutathione Peroxidase 4 Antibody / GPX4

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids A30-F197) was used as the immunogen for the Glutathione Peroxidase 4 antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the Glutathione Peroxidase 4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Glutathione Peroxidase 4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for GPX4

Target: GPX4 (Glutathione Peroxidase 4 (GPX4))

Alternative Name: Glutathione Peroxidase 4

Background: Glutathione peroxidase 4, also known as GPX4, is an enzyme that in humans is encoded by the GPX4 gene. This gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Alternative splicing results in multiple transcript variants.

UniProt: P36969