HTRA2 antibody (AA 30-458)

Catalog No. ABIN7873586

This Rabbit Polyclonal antibody specifically detects HTRA2 in WB, ELISA, IF, IHC (p) and FACS. It exhibits reactivity toward Human.

Quick Overview for HTRA2 antibody (AA 30-458) (ABIN7873586)

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HTRA2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-HTRA2 Antibody

Binding Specificity: AA 30-458

Purpose: OMI Antibody / HTRA2

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived human recombinant protein (amino acids R30-E458) was used as the immunogen for the OMI antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the OMI antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the OMI Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for HTRA2

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Alternative Name: OMI

Background: Serine protease HTRA2, mitochondrial, also called Omi stress-regulated endoprotease (OMI), is an enzyme that in humans is encoded by the HTRA2 gene. This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms.

UniProt: O43464

Pathways: Positive Regulation of Endopeptidase Activity