Recombinant SOX11 antibody (AA 300-400)

Catalog No. ABIN7873609

The Rabbit Monoclonal anti-SOX11 antibody (Clone SOX11-3235R) (ABIN7873609) specifically detects SOX11 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant SOX11 antibody (AA 300-400) (ABIN7873609)

Target: SOX11 (SRY (Sex Determining Region Y)-Box 11 (SOX11))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SOX11 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SOX11-3235R

Product Details anti-SOX11 Antibody

Binding Specificity: AA 300-400

Purpose: Recombinant SOX11 Antibody

Purification: Protein A affinity chromatography

Immunogen: A portion of amino acids 300-400 from the human protein was used as the immunogen for the recombinant SOX11 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant SOX11 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant SOX11 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for SOX11

Target: SOX11 (SRY (Sex Determining Region Y)-Box 11 (SOX11))

Alternative Name: SOX11

Background: Recognizes a protein of ~47 kDa, identified as SOX11. This MAb is highly specific and does not cross-react with other members of the SOX-family. Mantle cell lymphoma (MCL) accounts for 5 % to 10 % of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of Cyclin D1. Cyclin D1 overexpression is the hallmark of MCL. However, approximately 5 %-10 % of MCLs lack Cyclin D1 expression and may be misdiagnosed. Almost all Cyclin D1-positive as well as Cyclin D1-negative MCL, show overexpression of SOX-11. The detection of this transcription factor is a useful biomarker for identifying true cyclin D1-negative MCL.

UniProt: P35716

Pathways: Tube Formation