SCARA5 antibody (AA 31-288)

Catalog No. ABIN7873777

The Rabbit Polyclonal anti-SCARA5 antibody (ABIN7873777) specifically detects SCARA5 in ELISA and WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SCARA5 antibody (AA 31-288) (ABIN7873777)

Target: SCARA5 (Scavenger Receptor Class A, Member 5 (SCARA5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCARA5 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-SCARA5 Antibody

Binding Specificity: AA 31-288

Purpose: SCARA5 Antibody / Scavenger receptor class A member 5

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human SCARA5 recombinant protein (Position: K31-R288) was used as the immunogen for the SCARA5 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SCARA5 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SCARA5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SCARA5

Target: SCARA5 (Scavenger Receptor Class A, Member 5 (SCARA5))

Alternative Name: SCARA5

Background: SCARA5 antibody detects Scavenger receptor class A member 5, a pattern recognition receptor that mediates endocytosis of modified lipoproteins and iron-bound ligands. The UniProt recommended name is Scavenger receptor class A member 5 (SCARA5). This type II transmembrane protein participates in host defense, cellular adhesion, and iron metabolism.

Functionally, SCARA5 antibody identifies a 495-amino-acid receptor consisting of a collagen-like domain, a coiled-coil stalk, and a C-terminal scavenger receptor cysteine-rich domain that binds various ligands. SCARA5 acts as a ferritin receptor, mediating non-transferrin-dependent iron uptake. It also recognizes bacterial components and oxidized lipoproteins, linking innate immune recognition with metabolic regulation.

The SCARA5 gene is located on chromosome 8p21.1 and is highly expressed in kidney, lung, and heart. SCARA5 localizes to the plasma membrane and endocytic vesicles, facilitating internalization of ferritin and other ligands. It contributes to maintaining iron homeostasis and protecting tissues from oxidative stress caused by excess free iron.

Pathologically, downregulation of SCARA5 expression has been reported in several cancers, including hepatocellular and renal carcinoma, suggesting a tumor suppressive role. By controlling iron uptake and reactive oxygen species balance, SCARA5 helps limit oxidative damage and cell proliferation. Research using SCARA5 antibody aids in studying iron metabolism, scavenger receptor function, and innate immunity.

SCARA5 antibody is validated for western blotting, immunohistochemistry, and flow cytometry to detect receptor expression in tissues and cells. NSJ Bioreagents provides SCARA5 antibody reagents optimized for studies of receptor-mediated endocytosis, iron homeostasis, and tumor biology.

Structurally, Scavenger receptor class A member 5 features a collagenous triple-helical domain that promotes trimerization and ligand binding, resembling other scavenger receptor family members. This antibody enables analysis of SCARA5i 1/2s contribution to innate immunity, oxidative stress defense, and cancer suppression.

UniProt: Q6ZMJ2

Pathways: Transition Metal Ion Homeostasis