SLC38A9 antibody (AA 33-450)

Catalog No. ABIN7874002

The Rabbit Polyclonal anti-SLC38A9 antibody (ABIN7874002) specifically detects SLC38A9 in ELISA, WB, IF and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SLC38A9 antibody (AA 33-450) (ABIN7874002)

Target: SLC38A9 (Solute Carrier Family 38, Member 9 (SLC38A9))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC38A9 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-SLC38A9 Antibody

Binding Specificity: AA 33-450

Purpose: SLC38A9 Antibody / URLC11

Purification: Antigen affinity purified

Immunogen: An E.coli-derived human recombinant protein (amino acids D33-Q450) was used as the immunogen for the SLC38A9 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SLC38A9 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SLC38A9 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SLC38A9

Target: SLC38A9 (Solute Carrier Family 38, Member 9 (SLC38A9))

Alternative Name: SLC38A9

Background: Solute carrier family 38 member 9 is a protein that in humans is encoded by the SLC38A9 gene. Sodium-coupled neutral amino acid transporter 9 (SLC38A9) is a lysosomal amino acid transporter, involved in the regulation of mechanistic target of rapamycin complex 1 (mTORC1) activity in response to amino acid levels within the lysosomal lumen. A sodium-couple amino acid transporter at the lysosome, SLC38A9, senses arginine from within the lysosome to convey arginine sufficiency to mTORC1. SLC38A9 forms a complex with other lysosomal resident proteins including the v-ATPase and a pentameric complex called Ragulator. v-ATPase function is necessary for mTORC1 activation, but the molecular mechanism of this regulation is currently unclear2. Ragulator binds strongly to the Rag GTPases and was shown to function as a guanine exchange factor (GEF) for RagA/B. Potentially SLC38A9 and the v-ATPase are able to regulate mTORC1 activity by modulating Ragulatori 1/2s GEF activity. RagA/B is not the only Rag GTPase that is regulated, but a Folliculin-FNIP2 complex is a GAP for RagC/D. In short, SLC38A9 is a functional component of the lysosomal amino acid sensing machinery involved in the control of mTORC1 activity, that underlies the regulation of the metabolic status and cellular responses to growth factors, energy, glucose and amino acid levels.

UniProt: Q8NBW4