SCP2 antibody (AA 33-547)

Catalog No. ABIN7874006

This Rabbit Polyclonal antibody specifically detects SCP2 in WB, ELISA and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SCP2 antibody (AA 33-547) (ABIN7874006)

Target: SCP2 (Sterol Carrier Protein 2 (SCP2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-SCP2 Antibody

Binding Specificity: AA 33-547

Purpose: SCP2 Antibody / Sterol carrier protein 2

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human SCP2 recombinant protein (Position: R33-L547) was used as the immunogen for the SCP2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SCP2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SCP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SCP2

Target: SCP2 (Sterol Carrier Protein 2 (SCP2))

Alternative Name: SCP2

Background: SCP2 antibody detects Sterol carrier protein 2, encoded by the SCP2 gene. Sterol carrier protein 2 is a non-specific lipid transfer protein involved in intracellular lipid metabolism, peroxisomal function, and cholesterol trafficking. SCP2 antibody provides researchers with a valuable reagent for studying lipid transport, peroxisomal disorders, and cholesterol regulation.

Sterol carrier protein 2 plays a critical role in binding and transferring a wide range of lipids, including cholesterol, fatty acids, and phospholipids. Research using SCP2 antibody has shown that it localizes to peroxisomes, mitochondria, and the cytosol, where it helps mediate transport between organelles. By facilitating lipid shuttling, SCP2 contributes to membrane biosynthesis, signaling, and energy metabolism.

Studies with SCP2 antibody have revealed that the protein is synthesized as a multifunctional peroxisomal enzyme complex containing both thiolase activity and lipid transfer function. This dual nature allows SCP2 to integrate fatty acid oxidation with lipid transport, making it essential for peroxisomal physiology. Loss of SCP2 activity disrupts cholesterol homeostasis and leads to peroxisome-related disease phenotypes.

Dysregulation of Sterol carrier protein 2 has been associated with metabolic disease, cancer, and neurodegeneration. Research using SCP2 antibody has shown that reduced expression alters cholesterol trafficking, contributing to lipid storage disorders. Elevated expression has been observed in tumors, where SCP2 enhances membrane biosynthesis and supports proliferation. These findings highlight its dual role in normal physiology and disease pathology.

SCP2 antibody is widely applied in immunohistochemistry, western blotting, and immunofluorescence. Immunohistochemistry demonstrates expression in liver, adrenal gland, and brain, western blotting quantifies levels in cell lines and tissues, immunofluorescence reveals localization to peroxisomes and cytoplasm. These methods make SCP2 antibody indispensable for lipid transport research.

By providing validated SCP2 antibody reagents, NSJ Bioreagents supports studies into lipid metabolism, peroxisomal disorders, and disease. Detection of Sterol carrier protein 2 provides researchers with insight into how lipid transfer proteins influence cellular function and pathology.

UniProt: P22307

Pathways: C21-Steroid Hormone Metabolic Process, Monocarboxylic Acid Catabolic Process