MSRA antibody (AA 34-215)

Catalog No. ABIN7874064

The Rabbit Polyclonal anti-MSRA antibody is suitable to detect MSRA in samples from Human, Mouse and Rat. It has been validated for WB, ICC, IF and ELISA.

Quick Overview for MSRA antibody (AA 34-215) (ABIN7874064)

Target: MSRA (Methionine Sulfoxide Reductase A (MSRA))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MSRA antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA

Product Details anti-MSRA Antibody

Binding Specificity: AA 34-215

Purpose: MSRA Antibody / Peptide methionine sulfoxide reductase A

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human MSRA recombinant protein (Position: Q34-N215) was used as the immunogen for the MSRA antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MSRA antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MSRA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MSRA

Target: MSRA (Methionine Sulfoxide Reductase A (MSRA))

Alternative Name: MSRA

Background: MSRA antibody detects Peptide methionine sulfoxide reductase A, encoded by the MSRA gene. Peptide methionine sulfoxide reductase A is an enzyme that reduces oxidized methionine residues in proteins, repairing oxidative damage and maintaining protein function. MSRA antibody provides researchers with a specific reagent for studying oxidative stress responses, protein repair, and aging.

Peptide methionine sulfoxide reductase A belongs to the methionine sulfoxide reductase family of antioxidant enzymes. Research using MSRA antibody has shown that it catalyzes the stereospecific reduction of methionine-S-sulfoxide back to methionine. This activity restores protein structure and function after oxidative damage, contributing to cellular protection against reactive oxygen species.

Studies with MSRA antibody have revealed that the enzyme is expressed in multiple tissues, including brain, liver, and heart. Its localization to cytoplasm and mitochondria allows it to safeguard proteins in compartments most vulnerable to oxidative stress. This dual localization emphasizes its importance in protecting cellular integrity.

Dysregulation of Peptide methionine sulfoxide reductase A has been linked to neurodegenerative disease, cardiovascular pathology, and aging. Research using MSRA antibody has shown that deficiency accelerates accumulation of damaged proteins, impairing neuronal survival and increasing vulnerability to oxidative stress. Conversely, overexpression of MSRA extends lifespan in model organisms and enhances resistance to oxidative injury. These findings suggest therapeutic potential in oxidative stress-related diseases.

MSRA antibody is widely used in western blotting, immunohistochemistry, and enzyme activity studies. Western blotting quantifies levels across tissues and conditions, immunohistochemistry demonstrates expression in brain and heart, and enzymatic assays confirm repair activity. These approaches make MSRA antibody indispensable in oxidative biology and aging research.

By supplying validated MSRA antibody reagents, NSJ Bioreagents supports studies into oxidative stress, protein repair, and disease. Detection of Peptide methionine sulfoxide reductase A provides researchers with insight into how antioxidant enzymes maintain protein quality and healthspan.

UniProt: Q9UJ68