RNLS antibody (AA 34-235)

Catalog No. ABIN7874067

The Mouse Monoclonal anti-RNLS antibody is suitable to detect RNLS in samples from Human. It has been validated for ELISA.

Quick Overview for RNLS antibody (AA 34-235) (ABIN7874067)

Target: RNLS (Renalase, FAD-Dependent Amine Oxidase (RNLS))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RNLS antibody is un-conjugated

Application: ELISA

Clone: RNLS-1940

Product Details anti-RNLS Antibody

Binding Specificity: AA 34-235

Purpose: Renalase Antibody

Purification: Protein G affinity

Immunogen: A portion of amino acids 34-235 from the human protein was used as the immunogen for the Renalase antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the Renalase antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Renalase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for RNLS

Target: RNLS (Renalase, FAD-Dependent Amine Oxidase (RNLS))

Alternative Name: Renalase

Background: Renalase is a 342 amino acid FAD-dependent amine oxidase that is highly expressed in kidney and is expressed at a lower level in heart, skeletal muscle and small intestine. Renalase is secreted in the blood by the kidney and it is thought to regulate cardiac function and systemic blood pressure. It is also suggested that Renalase functions as a hormone that metabolizes circulating catecholamines, which have an active role in the sympathetic and parasympathetic nervous systems. Individuals with chronic kidney disease and end-stage renal disease have markedly reduced levels of plasma Renalase than healthy individuals. Infusion of Renalase in animal models causes decrease in heart rate, cardiac contractility and blood pressure. Two isoforms of Renalase exist due to alternative splicing events.

UniProt: Q5VYX0