Vitamin D-Binding Protein antibody (AA 35-175)

Catalog No. ABIN7874135

This Mouse Monoclonal antibody specifically detects Vitamin D-Binding Protein in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Vitamin D-Binding Protein antibody (AA 35-175) (ABIN7874135)

Target: Vitamin D-Binding Protein (GC)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Vitamin D-Binding Protein antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: VDBP-4481

Product Details anti-Vitamin D-Binding Protein Antibody

Binding Specificity: AA 35-175

Purpose: VDBP Antibody / Vitamin D binding protein / GC

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 35-175 was used as the immunogen for the VDBP antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the VDBP antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the VDBP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Vitamin D-Binding Protein

Target: Vitamin D-Binding Protein (GC)

Alternative Name: VDBP

Background: Vitamin D-binding protein (DBP) is a multi-functional serum protein that binds to the plasma membranes of numerous cell types and mediates a variety of cellular functions. The locus of the DBP protein (also known as group-specific component protein or GC) is located at human chromosome 4q13.3. DBP functions in organ-specific transportation of vitamin D and its metabolites to the various target organs of the vitamin D endocrine system. In addition, DBP has immunomodulatory properties and is able to bind to the surface of leukocytes. DBP binds to the plasma membrane through a chondroitin sulfate proteoglycan. DBP serves as a co-chemotactic factor for C5a to enhance the chemotactic activity of C5a. DBP can also bind to globular Actin with high affinity and is involved in the clearance of Actin from the blood. DBP plays an important role in osteoclast differentiation. The diverse cellular functions of DBP require its cell surface binding ability to mediate different biological processes.

UniProt: P02774

Pathways: Metabolism of Steroid Hormones and Vitamin D, Monocarboxylic Acid Catabolic Process