C1orf92 antibody (AA 35-543)

Catalog No. ABIN7874171

This Rabbit Polyclonal antibody specifically detects C1orf92 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for C1orf92 antibody (AA 35-543) (ABIN7874171)

Target: C1orf92 (LRRC71) (Leucine Rich Repeat Containing 71 (LRRC71))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C1orf92 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-C1orf92 Antibody

Binding Specificity: AA 35-543

Purpose: LRRC71 Antibody / Leucine-rich repeat-containing protein 71

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human C1orf92/LRRC71 recombinant protein (Position: K35-D543) was used as the immunogen for the LRRC71 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the LRRC71 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the LRRC71 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for C1orf92

Target: C1orf92 (LRRC71) (Leucine Rich Repeat Containing 71 (LRRC71))

Alternative Name: LRRC71

Background: LRRC71 antibody detects Leucine-rich repeat-containing protein 71, a cytoplasmic and possibly nuclear protein characterized by multiple leucine-rich repeat motifs involved in protein-protein interactions. While the precise biological function of LRRC71 is still being elucidated, members of the leucine-rich repeat (LRR) family are commonly associated with cellular signaling, adhesion, and developmental regulation. The LRRC71 antibody is used in studies examining protein interaction networks, signal transduction pathways, and the potential roles of LRR proteins in neuronal and reproductive biology.

LRRC71 is encoded by the LRRC71 gene located on human chromosome 8q24.3. The protein contains tandem LRR motifs forming a horseshoe-shaped structure that facilitates binding to various partners, including receptors, kinases, and cytoskeletal proteins. Bioinformatic analyses suggest roles in cell differentiation and communication, possibly through modulation of receptor signaling. Expression profiling has revealed LRRC71 mRNA in multiple tissues, with enrichment in testis, brain, and epithelial organs, indicating possible participation in spermatogenesis and neurodevelopment.

Using the LRRC71 antibody, researchers can detect a band between 60-70 kilodaltons on western blot, corresponding to the predicted molecular weight of the protein. Immunostaining studies show cytoplasmic and perinuclear localization, consistent with a signaling or adaptor function. Although direct physiological functions remain under active investigation, related LRR family members are known to mediate receptor clustering and intracellular scaffolding, suggesting a conserved molecular role for LRRC71 in signal integration and cell organization.

Emerging data suggest LRRC71 may interact with intracellular components regulating calcium signaling or vesicular trafficking. Its predicted structural features imply involvement in membrane-proximal signaling complexes that respond to developmental or stress cues. Further investigation may also link LRRC71 to fertility regulation, as several LRR proteins participate in germ cell communication and acrosome formation. NSJ Bioreagents provides a validated LRRC71 antibody optimized for western blot, immunofluorescence, and immunohistochemistry applications, supporting research into LRR protein structure, signaling, and cellular differentiation.

UniProt: Q8N4P6