Recombinant KRT14 antibody (AA 350-472)

Catalog No. ABIN7874197

The Rabbit Monoclonal anti-KRT14 antibody (Clone KRT14-7054R) (ABIN7874197) specifically detects KRT14 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant KRT14 antibody (AA 350-472) (ABIN7874197)

Target: KRT14 (Keratin 14 (KRT14))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This KRT14 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: KRT14-7054R

Product Details anti-KRT14 Antibody

Binding Specificity: AA 350-472

Purpose: Recombinant Cytokeratin 14 Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A recombinant human KRT14 fragment (within amino acids 350-472) was used as the immunogen for the recombinant Cytokeratin 14 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant Cytokeratin 14 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the recombinant Cytokeratin 14 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for KRT14

Target: KRT14 (Keratin 14 (KRT14))

Alternative Name: Cytokeratin 14

Background: Cytokeratin 14 is a member of the type I keratin family of intermediate filament proteins. It always pairs with the type II keratin K5 and form the primary keratin pair of the keratinocytes of stratified squamous epithelia, including the epidermis as well as mucosal non-keratinizing stratified squamous epithelia.Cytokeratin 14 is strongly expressed in the undifferentiated basal cell layer containing the stem cells and are down-regulated in the differentiating suprabasal cell layers. Otherwise, in the widely well stratified follicular outer root sheath, cytokeratin 14 is uniformly expressed throughout all layers. The expression spectrum of cytokeratin 14 in tumors corresponds well to the patterns in normal epithelia. Thus, most squamous cell carcinomas as well as malignant mesotheliomas strongly express this keratin whereas little, focal, or no expression is found in adenocarcinomas.Cytokeratin 14 may be a useful marker in the differential diagnosis of squamous cell carcinoma from other epithelial tumors. Recent studies also indicate that CK14 expression in breast cancer corresponded with poor clinical outcome and that CK14 may have diagnostic value in the sub-classification of NSCLC.

UniProt: P02533