SPTA1 antibody (AA 356-475)

Catalog No. ABIN7874268

The Mouse Monoclonal anti-SPTA1 antibody is suitable to detect SPTA1 in samples from Human. It has been validated for WB, ELISA and IHC (p).

Quick Overview for SPTA1 antibody (AA 356-475) (ABIN7874268)

Target: SPTA1 (Spectrin alpha 1, Erythrocytic (SPTA1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SPTA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SPTA1-1832

Product Details anti-SPTA1 Antibody

Binding Specificity: AA 356-475

Purpose: Spectrin alpha 1 Antibody / SPTA1

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 356-475 from the human protein was used as the immunogen for the Spectrin alpha 1 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the Spectrin alpha 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Spectrin alpha 1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for SPTA1

Target: SPTA1 (Spectrin alpha 1, Erythrocytic (SPTA1))

Alternative Name: Spectrin alpha 1

Background: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. Spectrins function as membrane organizers and stabilizers, composed of non-homologous and chains, which aggregate side-to-side in an anti-parallel fashion to form dimers, tetramers and higher polymers. Spectrin Ia and spectrin Ib are present in erythrocytes, whereas spectrin IIa (also designated fodrin alpha) and spectrin IIb (also designated fodrin beta) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function.

UniProt: P02549

Pathways: Regulation of Actin Filament Polymerization