Kallikrein 5 antibody (AA 36-177)

Catalog No. ABIN7874300

This Mouse Monoclonal antibody specifically detects Kallikrein 5 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Kallikrein 5 antibody (AA 36-177) (ABIN7874300)

Target: Kallikrein 5 (KLK5)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Kallikrein 5 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: KLK5-3841

Product Details anti-Kallikrein 5 Antibody

Binding Specificity: AA 36-177

Purpose: Kallikrein 5 Antibody

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 36-177 from the human protein was used as the immunogen for the Kallikrein 5 antibody.

Isotype: IgG2c, kappa

Application Details

Application Notes: Optimal dilution of the Kallikrein 5 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Kallikrein 5 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Kallikrein 5

Target: Kallikrein 5 (KLK5)

Alternative Name: Kallikrein 5

Background: Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Human pancreatic/renal KLK encodes for the KLK1 enzyme, which is involved in post-translational processing of polypeptide precursors. The function of the other members of KLK gene family is still currently unknown, but evidence suggests that many KLKs are implicated in carcinogenesis. The human KLK gene family consists of 15 serine proteases. The human KLK genes are clustered on chromosome 19q13. Unlike other kalllikreins, the KLK4-15 encoded proteases are less related and do not contain a conventional KLK loop. Clusters of genes exhibit high prostatic (KLK2-4, KLK15) or pancreatic (KLK6-13) expression. KLK2 is also known as glandular kallikrein 2, tissue kallikrein, or HGK-1 and KLK3 is known as prostate-specific antigen (PSA). Both KLK2 and KLK3 have important applications in prostate cancer and breast cancer diagnostics. Many of the KLKs are regulated by steroid hormones and a few of them, specifically KLK3, KLK6 and KLK10, are known to be downregulated in breast and other cancers. KLK5 expression is abundant in skin, mammary gland and testis.

UniProt: Q9Y337

Pathways: Complement System, Regulation of G-Protein Coupled Receptor Protein Signaling