PDE12 antibody (AA 36-607)

Catalog No. ABIN7874325

The Rabbit Polyclonal anti-PDE12 antibody is suitable to detect PDE12 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and FACS.

Quick Overview for PDE12 antibody (AA 36-607) (ABIN7874325)

Target: PDE12 (Phosphodiesterase 12 (PDE12))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE12 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-PDE12 Antibody

Binding Specificity: AA 36-607

Purpose: PDE12 Antibody / Mitochondrial deadenylase / 2',5'-phosphodiesterase 12

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived human recombinant protein (amino acids E36-K607) was used as the immunogen for the PDE12 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PDE12 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PDE12 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PDE12

Target: PDE12 (Phosphodiesterase 12 (PDE12))

Alternative Name: PDE12

Background: PDE12 is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. It also cleaves 3',5'-phosphodiester bond of oligoadenylates and plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

UniProt: Q6L8Q7