INHBB antibody (AA 369-397)

Catalog No. ABIN7874377

The Rabbit Polyclonal anti-INHBB antibody (ABIN7874377) specifically detects INHBB in WB and IHC (p). The antibody is reactive with Human and Mouse samples.

Quick Overview for INHBB antibody (AA 369-397) (ABIN7874377)

Target: INHBB (Inhibin, beta B (INHBB))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INHBB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-INHBB Antibody

Binding Specificity: AA 369-397

Purpose: Inhibin beta B chain Antibody / INHBB

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 369-397 from the human protein was used as the immunogen for the Inhibin beta B chain antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Inhibin beta B chain antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Inhibin beta B chain antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for INHBB

Target: INHBB (Inhibin, beta B (INHBB))

Alternative Name: Inhibin beta B chain

Background: The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.

UniProt: P09529

Pathways: Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion