PLD6 antibody (AA 39-238)

Catalog No. ABIN7874591

This Rabbit Polyclonal antibody specifically detects PLD6 in ELISA, WB, IF, FACS and IHC (p). It exhibits reactivity toward Human.

Quick Overview for PLD6 antibody (AA 39-238) (ABIN7874591)

Target: PLD6 (Phospholipase D Family, Member 6 (PLD6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLD6 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PLD6 Antibody

Binding Specificity: AA 39-238

Purpose: PLD6 Antibody / Phospholipase D6 / MitoPLD

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids R39-L238) was used as the immunogen for the PLD6 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PLD6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PLD6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PLD6

Target: PLD6 (Phospholipase D Family, Member 6 (PLD6))

Alternative Name: PLD6

Background: PLD6 (phospholipase D family, member 6), also called MitoPLD (Mitochondrial phospholipase), is a protein-coding gene. Among its related super-pathways are choline biosynthesis III and Glycerophospholipid biosynthesis. GO annotations related to this gene include cardiolipin hydrolase activity and protein homodimerization activity. Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity (By similarity). Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol.

UniProt: Q8N2A8

Pathways: Ribonucleoprotein Complex Subunit Organization