BCL9L antibody (AA 397-666)

Catalog No. ABIN7874649

The Rabbit Polyclonal anti-BCL9L antibody is suitable to detect BCL9L in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, IF and IHC (p).

Quick Overview for BCL9L antibody (AA 397-666) (ABIN7874649)

Target: BCL9L (B-Cell CLL/lymphoma 9-Like (BCL9L))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL9L antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-BCL9L Antibody

Binding Specificity: AA 397-666

Purpose: BCL9L Antibody

Purification: Affinity purified

Immunogen: Amino acids E397-A666 from the human protein were used as the immunogen for the BCL9L antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the BCL9L antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: Store the BCL9L antibody at -20oC.

Target Details for BCL9L

Target: BCL9L (B-Cell CLL/lymphoma 9-Like (BCL9L))

Alternative Name: BCL9L

Background: B-cell CLL/lymphoma 9 like is a protein that in humans is encoded by the BCL9L gene. It is mapped to 11q23.3. Bcl-9 (B-cell lymphoma 9, also Protein legless homolog) is a transcriptional regulator that belongs to the Bcl-9 family of proteins. It is expressed in multiple tissues and serves to recruit Pygopus to the Wnt-pathway beta -catenin-TCF complex in the nucleus. Bcl-9 and Bcl-9-2 are considered evolutionary duplicates of Legless that perform the same task with different regulation. Human Bcl-9 is 1426 amino acids (aa) in length. It contains one phosphothreonine and three phosphoserine sites that have been identified so far, two poly-Pro regions (aa 514?517 and 970?973), and one poly-Ala segment (aa 900?903). There is one potential alternate start site at Met27, and a variant isoform exists that shows a four aa substitution for aa 1391?1426. Over aa 1009?1328, human Bcl-9 is 96 % aa identical to mouse Bcl-9.

UniProt: Q86UU0

Pathways: Stem Cell Maintenance