NEFL antibody (AA 4-463)

Catalog No. ABIN7874679

The Rabbit Polyclonal anti-NEFL antibody is suitable to detect NEFL in samples from Human, Rat and Mouse. It has been validated for WB, ELISA, IF, FACS and IHC (p).

Quick Overview for NEFL antibody (AA 4-463) (ABIN7874679)

Target: NEFL (Neurofilament, Light Polypeptide (NEFL))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NEFL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-NEFL Antibody

Binding Specificity: AA 4-463

Purpose: Neurofilament Light Antibody / NF-L

Purification: Affinity purified

Immunogen: A human recombinant partial protein (amino acids F4-A463) was used as the immunogen for the Neurofilament Light antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Neurofilament Light antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Neurofilament Light antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for NEFL

Target: NEFL (Neurofilament, Light Polypeptide (NEFL))

Alternative Name: Neurofilament Light

Background: Neurofilament light polypeptide (NFL), also known as neurofilament light chain, is a neurofilament protein that in humans is encoded by the NEFL gene. Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.

UniProt: P07196