Stonin 2 (STON2) (AA 4-855) antibody

Catalog No. ABIN7874686

The Rabbit Polyclonal anti-Stonin 2 antibody (ABIN7874686) specifically detects Stonin 2 in WB, ELISA, FACS, IF and IHC (p). The antibody is reactive with Human samples.

Quick Overview for Stonin 2 (STON2) (AA 4-855) antibody (ABIN7874686)

Target: Stonin 2 (STON2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details

Binding Specificity: AA 4-855

Purpose: STON2 Antibody / Stonin 2

Purification: Antigen affinity purified

Immunogen: Amino acids L4-K855 from the human protein were used as the immunogen for the STON2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the STON2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the STON2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details

Target: Stonin 2 (STON2)

Alternative Name: STON2

Background: STON2 (Stonin 2) is a member of the stonin protein family, which plays an important role in clathrin-mediated endocytosis. It functions as an adaptor protein that interacts with components of the endocytic machinery, including clathrin and adaptor protein complexes, to facilitate the internalization of synaptic vesicle proteins and receptors. By regulating vesicle recycling, STON2 contributes to synaptic transmission and receptor turnover. Researchers often use a STON2 antibody to study endocytosis, neuronal signaling, and membrane trafficking.

STON2 contains multiple protein interaction motifs, including proline-rich domains and endocytic sorting signals, which allow it to engage with dynamin and AP-2 complex subunits. These interactions position STON2 as a bridge between cargo proteins and the vesicle formation machinery. Employing a STON2 antibody enables the investigation of how this adaptor protein regulates cargo selection and vesicle budding in both neuronal and non-neuronal systems.

Disruption of STON2 function has been linked to neurological and psychiatric conditions, as defects in synaptic vesicle recycling can impair neurotransmission. In addition, STON2 has been implicated in receptor internalization pathways outside the nervous system, suggesting broader roles in endocytic regulation. Studying STON2 with a STON2 antibody provides valuable insights into how defects in endocytosis contribute to disease mechanisms and may highlight potential therapeutic targets.

NSJ Bioreagents provides a high-quality STON2 antibody validated for applications including western blot, immunohistochemistry, and immunofluorescence. Choosing a STON2 antibody from NSJ Bioreagents ensures reliable performance and reproducibility in studies of clathrin-mediated endocytosis, synaptic biology, and receptor regulation.

UniProt: Q8WXE9