SRPX antibody (AA 40-464)

Catalog No. ABIN7874703

The Rabbit Polyclonal anti-SRPX antibody is suitable to detect SRPX in samples from Human. It has been validated for WB and ELISA.

Quick Overview for SRPX antibody (AA 40-464) (ABIN7874703)

Target: SRPX (Sushi-Repeat Containing Protein, X-Linked (SRPX))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRPX antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SRPX Antibody

Binding Specificity: AA 40-464

Purpose: SRPX Antibody / Sushi repeat-containing protein X-linked

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human SRPX recombinant protein (Position: E40-T464) was used as the immunogen for the SRPX antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SRPX antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SRPX antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SRPX

Target: SRPX (Sushi-Repeat Containing Protein, X-Linked (SRPX))

Alternative Name: SRPX

Background: SRPX antibody detects Sushi repeat-containing protein X-linked, a secreted and membrane-associated glycoprotein encoded by the SRPX gene located on chromosome Xq22.1. SRPX is a member of the sushi repeat (also called complement control protein or CCP) family, characterized by tandemly repeated domains that mediate protein-protein interactions involved in immune signaling, cell adhesion, and extracellular matrix organization. The SRPX protein localizes to the extracellular space and plasma membrane, where it participates in cellular communication, angiogenesis, and synaptic remodeling.

SRPX antibody identifies a multifunctional protein expressed in various tissues, including the brain, lung, and vascular endothelium. Within the extracellular environment, SRPX acts as an adhesion molecule that facilitates interactions between cells and matrix components. It is upregulated during wound healing and tissue remodeling, suggesting a role in extracellular matrix turnover and endothelial migration. SRPX contains three sushi domains, an N-terminal signal peptide, and glycosylation sites that support secretion and stability in the extracellular milieu.

In the nervous system, SRPX contributes to synapse formation and refinement. A related paralog, SRPX2, has been implicated in synaptic development and language-associated brain disorders, suggesting possible functional overlap within this protein family. SRPX also interacts with urokinase-type plasminogen activator receptor (uPAR) and complement components, supporting its role in both immune regulation and neurodevelopment. The presence of sushi domains links SRPX to complement control proteins that regulate immune activation and inflammation. Functional studies suggest that SRPX can influence cell migration, angiogenic responses, and matrix protease activity, making it relevant in vascular biology and tumor progression.

Clinically, altered SRPX expression has been observed in cancer, where it may contribute to tumor angiogenesis and metastasis. Overexpression has been reported in certain carcinomas, whereas decreased expression may impair extracellular signaling and cell adhesion. SRPX mutations have been studied in relation to X-linked intellectual disability and speech delay, although functional evidence remains limited. The SRPX gene resides in a genomic region frequently associated with inherited neurological disorders and may have regulatory overlap with neighboring genes involved in synaptic signaling.

From a structural standpoint, SRPX shares sequence homology with complement control proteins and contains conserved cysteine residues essential for disulfide bond formation. Its extracellular localization allows it to function as a scaffold in tissue remodeling and immune recognition. The protein family classification places SRPX among sushi domain-containing adhesion molecules, emphasizing its dual role in immune defense and neuronal plasticity.

Immunohistochemical analysis using SRPX antibody demonstrates extracellular and membrane-associated localization in endothelial cells, neurons, and epithelial tissues. The SRPX antibody from NSJ Bioreagents provides a useful reagent for studying sushi repeat proteins, angiogenesis, and cell-matrix interactions relevant to both neural and vascular biology.

UniProt: P78539