GIT2 antibody (AA 400-556)

Catalog No. ABIN7874728

The Rabbit Polyclonal anti-GIT2 antibody (ABIN7874728) specifically detects GIT2 in WB, ELISA and FACS. The antibody is reactive with Human and Mouse samples.

Quick Overview for GIT2 antibody (AA 400-556) (ABIN7874728)

Target: GIT2 (G Protein-Coupled Receptor Kinase Interactor 2 (GIT2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GIT2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-GIT2 Antibody

Binding Specificity: AA 400-556

Purpose: GIT2 Antibody / GRK-interacting protein 2

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids D400-S556) was used as the immunogen for the GIT2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GIT2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the GIT2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for GIT2

Target: GIT2 (G Protein-Coupled Receptor Kinase Interactor 2 (GIT2))

Alternative Name: GIT2

Background: ARF GTPase-activating protein GIT2 is an enzyme that in humans is encoded by the GIT2 gene. This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.

UniProt: Q14161

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling