MX1 antibody (AA 400-592)

Catalog No. ABIN7874740

The Mouse Monoclonal anti-MX1 antibody (Clone MX1-7527) (ABIN7874740) specifically detects MX1 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for MX1 antibody (AA 400-592) (ABIN7874740)

Target: MX1 (Myxovirus Resistance Protein 1 (MX1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MX1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MX1-7527

Product Details anti-MX1 Antibody

Binding Specificity: AA 400-592

Purpose: MX1 Antibody / Myxovirus resistance protein 1 / MxA

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 400-592) from the human protein was used as the immunogen for the MX1 antibody.

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal dilution of the MX1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the MX1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for MX1

Target: MX1 (Myxovirus Resistance Protein 1 (MX1))

Alternative Name: MX1

Background: The Dynamin family of microtubule-associated proteins function as GTPases that are involved in microtubule bundling and endocytosis. In mice, Mx2 (myxovirus resistance protein 2) and Mx1 (myxovirus resistance protein 1) are members of the Dynamin family that are involved in the immune response to viral infections. Localized to the cytoplasm, Mx2 contains one GED domain and is expressed in response to viral infection or treatment by IFN-a/IFN-b. Once expression is induced, Mx2 accumulates in the cytoplasm and inhibits the replication of vesicular stomatitis virus (VSV), thereby conferring resistance to VSV infection. Unlike Mx2, Mx1 is localized to the nucleus where, upon induction by IFN-a/IFN-b, it provides selective resistance to infection by the highly lethal H5N1 influenza virus. In humans, MxA and MxB function in a similar manner to Mx1 and Mx2, conferring resistance to specific target viruses. Mx3 is a rat-specific member of the myxovirus resistance protein family.

UniProt: P20591