MYBBP1A antibody (AA 41-1058)

Catalog No. ABIN7874821

The Rabbit Polyclonal anti-MYBBP1A antibody (ABIN7874821) specifically detects MYBBP1A in WB, ELISA, IF, ICC and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for MYBBP1A antibody (AA 41-1058) (ABIN7874821)

Target: MYBBP1A (Myb-Binding Protein 1A (MYBBP1A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYBBP1A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Product Details anti-MYBBP1A Antibody

Binding Specificity: AA 41-1058

Purpose: MYBBP1A Antibody / Myb-binding protein 1A

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human MYBBP1A recombinant protein (Position: D41-Q1058) was used as the immunogen for the MYBBP1A antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MYBBP1A antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MYBBP1A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MYBBP1A

Target: MYBBP1A (Myb-Binding Protein 1A (MYBBP1A))

Alternative Name: MYBBP1A

Background: MYBBP1A antibody detects Myb-binding protein 1A, encoded by the MYBBP1A gene. Myb-binding protein 1A is a nucleolar protein that participates in transcriptional regulation, ribosome biogenesis, and stress signaling. MYBBP1A antibody provides researchers with a versatile reagent for studying nuclear protein interactions, tumor suppression, and stress-responsive transcriptional programs.

Myb-binding protein 1A was first identified as a factor that interacts with the transcription factor c-Myb. Research using MYBBP1A antibody has shown that it acts as a transcriptional regulator by modulating Myb-dependent genes and other transcriptional pathways. It functions as a co-repressor or co-activator depending on cellular context, influencing cell proliferation and differentiation.

Studies with MYBBP1A antibody have revealed that the protein localizes to the nucleolus under basal conditions but translocates to the nucleoplasm upon cellular stress. This dynamic distribution links ribosome biogenesis to stress-responsive transcriptional regulation. MYBBP1A influences ribosomal RNA transcription, p53 activation, and chromatin remodeling, emphasizing its multifunctional nature.

Dysregulation of Myb-binding protein 1A has been linked to cancer and stress-related pathology. Research using MYBBP1A antibody has shown that reduced expression contributes to tumorigenesis by impairing p53-mediated responses. Conversely, overexpression can suppress tumor growth by activating apoptosis pathways. This dual role highlights its complex involvement in cancer biology.

Beyond cancer, MYBBP1A participates in metabolic regulation and cellular senescence. Research using MYBBP1A antibody has suggested roles in controlling NF-kB signaling, mitochondrial stress responses, and transcription of metabolic genes. These findings underscore its integration of stress responses with transcriptional networks.

MYBBP1A antibody is widely applied in western blotting, immunohistochemistry, and chromatin immunoprecipitation. Western blotting quantifies protein levels, immunohistochemistry demonstrates nucleolar localization, and chromatin immunoprecipitation identifies transcriptional binding partners. These applications make MYBBP1A antibody indispensable in nuclear biology and cancer research.

By providing validated MYBBP1A antibody reagents, NSJ Bioreagents supports studies into transcriptional regulation, stress signaling, and tumor suppression. Detection of Myb-binding protein 1A provides researchers with insight into how nucleolar proteins integrate ribosome biogenesis and stress responses.

UniProt: Q9BQG0