Cathepsin B antibody (AA 42-339)

Catalog No. ABIN7874922

The Rabbit Polyclonal anti-Cathepsin B antibody is suitable to detect Cathepsin B in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, FACS and IHC (p).

Quick Overview for Cathepsin B antibody (AA 42-339) (ABIN7874922)

Target: Cathepsin B (CTSB)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathepsin B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Cathepsin B Antibody

Binding Specificity: AA 42-339

Purpose: CTSB Antibody / Cathepsin B

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids Q42-K339) was used as the immunogen for the CTSB antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CTSB antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the CTSB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Cathepsin B

Target: Cathepsin B (CTSB)

Alternative Name: CTSB

Background: Cathepsin B is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSB gene. And this gene is mapped to chromosome 8p22. The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. Cathepsin B was once suspected as a candidate protease participating in the conversion of beta-amyloid precursor protein into the amyloid plaques found in Alzheimer's disease patients. However, this function is now known to be mediated by BACE1 protease. It is now thought that cathepsin B can degrade beta-amyloid precursor protein into harmless fragments. Thus, it is conceivable cathepsin B may play a pivotal role in the natural defense against Alzheimer's disease. Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.

UniProt: P07858

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades