STK32C antibody (AA 42-475)

Catalog No. ABIN7874926

The Rabbit Polyclonal anti-STK32C antibody (ABIN7874926) specifically detects STK32C in ELISA, WB and FACS. The antibody is reactive with Human samples.

Quick Overview for STK32C antibody (AA 42-475) (ABIN7874926)

Target: STK32C (serine/threonine Kinase 32C (STK32C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STK32C antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-STK32C Antibody

Binding Specificity: AA 42-475

Purpose: STK32C Antibody / Serine/threonine-protein kinase 32C

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human STK32C recombinant protein (Position: Q42-M475) was used as the immunogen for the STK32C antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the STK32C antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the STK32C antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for STK32C

Target: STK32C (serine/threonine Kinase 32C (STK32C))

Alternative Name: STK32C

Background: STK32C antibody detects Serine/threonine-protein kinase 32C, a member of the STK32 family of kinases that includes STK32A and STK32B. STK32C is a cytoplasmic serine/threonine kinase involved in signal transduction pathways regulating cellular growth, metabolism, and stress responses. Although less characterized than its paralogs, STK32C has emerging importance in neuronal signaling and mitochondrial regulation. The STK32C antibody is used in research investigating kinase signaling networks, neurodevelopment, and protein phosphorylation control.

STK32C is encoded by the STK32C gene located on human chromosome 5q35.1. The protein is approximately 56 kilodaltons and contains a conserved serine/threonine kinase catalytic domain with typical subdomains I-XI, including an ATP-binding site and an activation loop. Expression profiling shows broad distribution across tissues, with enriched levels in brain, heart, and skeletal muscle, suggesting roles in excitable tissue function and mitochondrial homeostasis.

STK32C phosphorylates substrates involved in metabolic regulation and cytoskeletal dynamics, though its full substrate repertoire remains under study. In neuronal systems, STK32C expression increases during differentiation, implying a developmental regulatory function. Comparative analysis with STK32A and STK32B reveals overlapping but distinct substrate preferences and signaling responses, highlighting potential functional diversification among this kinase subfamily.

Recent phosphoproteomic analyses indicate that STK32C may participate in stress-activated signaling and mitochondrial fission control. Inhibition or silencing of STK32C disrupts mitochondrial morphology and reduces oxidative phosphorylation efficiency. This kinase may integrate metabolic status with energy homeostasis by phosphorylating mitochondrial or cytosolic target proteins. Additionally, preliminary data suggest a role in autophagic flux modulation and endoplasmic reticulum-mitochondria communication.

In cancer biology, STK32C has been implicated in cellular proliferation and invasion through phosphorylation of cytoskeletal effectors. Elevated expression correlates with poor prognosis in certain neuroblastoma and glioblastoma datasets, suggesting possible oncogenic behavior in nervous system tumors. In contrast, other studies report STK32C downregulation in degenerative neural conditions, implying context-dependent effects. The enzyme's unique sequence features, including an elongated C-terminal tail and regulatory motifs, suggest fine-tuned signaling modulation. NSJ Bioreagents provides a validated STK32C antibody optimized for its applications, enabling detailed investigation of serine/threonine kinase signaling and cellular metabolic adaptation.

UniProt: Q86UX6