GAS2L2 antibody (AA 43-829)

Catalog No. ABIN7874975

This Rabbit Polyclonal antibody specifically detects GAS2L2 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for GAS2L2 antibody (AA 43-829) (ABIN7874975)

Target: GAS2L2 (Growth Arrest-Specific 2 Like 2 (GAS2L2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GAS2L2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-GAS2L2 Antibody

Binding Specificity: AA 43-829

Purpose: GAS2L2 Antibody / Growth arrest-specific protein 2-like 2

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human GAS2L2 recombinant protein (Position: R43-R829) was used as the immunogen for the GAS2L2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GAS2L2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the GAS2L2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for GAS2L2

Target: GAS2L2 (Growth Arrest-Specific 2 Like 2 (GAS2L2))

Alternative Name: GAS2L2

Background: GAS2L2 antibody detects Growth arrest-specific protein 2-like 2, a cytoskeletal-associated protein that links microtubules and actin filaments. GAS2L2 contributes to cell shape maintenance, mechanical stability, and tissue organization. The GAS2L2 antibody is used to study cytoskeleton interactions, cell polarity, and epithelial morphogenesis.

GAS2L2 is encoded by the GAS2L2 gene on human chromosome 17p13.1. The protein is approximately 97 kilodaltons and contains a calponin homology (CH) domain that binds actin and a GAS2-related (GAR) domain that associates with microtubules. This dual-binding capability enables GAS2L2 to coordinate actin-microtubule crosslinking, influencing cell architecture and mechanotransduction.

The GAS2L2 antibody reveals filamentous and junctional staining in epithelial and smooth muscle cells. GAS2L2 expression is enriched in respiratory and reproductive epithelia, where it stabilizes apical cell-cell contacts. Loss of GAS2L2 disrupts ciliogenesis and planar cell polarity, leading to impaired epithelial alignment and fluid transport. In fibroblasts and neurons, GAS2L2 contributes to microtubule organization and axonal guidance.

Beyond structural support, GAS2L2 regulates cell migration and wound healing by modulating actin polymerization dynamics. It interacts with signaling proteins that respond to mechanical stress, suggesting a role in tissue homeostasis and mechanosensitive pathways. Mutations or altered expression of GAS2L2 are associated with ciliary dysfunction and airway remodeling disorders.

Because of its crosslinking function, GAS2L2 serves as a molecular bridge between cytoskeletal networks, coordinating force generation and cellular tension. NSJ Bioreagents provides a validated GAS2L2 antibody, supporting research into epithelial organization, mechanical signaling, and cell polarity regulation.

UniProt: Q8NHY3