CLPB antibody (AA 438-707)

Catalog No. ABIN7875000

The Rabbit Polyclonal anti-CLPB antibody is suitable to detect CLPB in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, IHC (p), FACS and IF.

Quick Overview for CLPB antibody (AA 438-707) (ABIN7875000)

Target: CLPB (ClpB Caseinolytic Peptidase B Homolog (CLPB))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLPB antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (IF)

Product Details anti-CLPB Antibody

Binding Specificity: AA 438-707

Purpose: CLPB Antibody / Caseinolytic peptidase B protein

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids Q438-I707) was used as the immunogen for the CLPB antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CLPB antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the CLPB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CLPB

Target: CLPB (ClpB Caseinolytic Peptidase B Homolog (CLPB))

Alternative Name: CLPB

Background: This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants.

UniProt: Q9H078