Filamin A antibody (AA 451-638)

Catalog No. ABIN7875095

This Mouse Monoclonal antibody specifically detects Filamin A in WB, IF and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Filamin A antibody (AA 451-638) (ABIN7875095)

Target: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Filamin A antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 3F8

Product Details anti-Filamin A Antibody

Binding Specificity: AA 451-638

Purpose: FLNA Antibody / Filamin A

Purification: Affinity purified

Immunogen: A human recombinant partial protein (amino acids E451-Q638) was used as the immunogen for the FLNA antibody.

Isotype: IgG1

Application Details

Application Notes: Optimal dilution of the FLNA antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the FLNA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Filamin A

Target: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Alternative Name: FLNA

Background: Filamin A, alpha (FLNA) is a protein that in humans is encoded by the FLNA gene. It is mapped to Xq28. The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.

UniProt: P21333

Pathways: TCR Signaling, Maintenance of Protein Location