RNF34 antibody (AA 46-372)

Catalog No. ABIN7875119

This Rabbit Polyclonal antibody specifically detects RNF34 in WB, ELISA, IHC (p), IF and FACS. It exhibits reactivity toward Human.

Quick Overview for RNF34 antibody (AA 46-372) (ABIN7875119)

Target: RNF34 (Ring Finger Protein 34 (RNF34))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF34 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-RNF34 Antibody

Binding Specificity: AA 46-372

Purpose: RNF34 Antibody / hRFI / CARP-1

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids E46-S372) was used as the immunogen for the RNF34 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the RNF34 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the RNF34 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for RNF34

Target: RNF34 (Ring Finger Protein 34 (RNF34))

Alternative Name: RNF34

Background: E3 ubiquitin-protein ligase RNF34, also called Human RING finger homologous to inhibitor of apoptosis protein (hRFI) and Caspases-8 and -10-associated RING finger protein 1 (CARP-1) is an enzyme that in humans is encoded by the RNF34 gene. The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms.

UniProt: Q969K3