Seryl-tRNA Synthetase (SARS) (AA 46-518) antibody

Catalog No. ABIN7875122

This Rabbit Polyclonal antibody specifically detects Seryl-tRNA Synthetase in WB, ELISA, IF and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Seryl-tRNA Synthetase (SARS) (AA 46-518) antibody (ABIN7875122)

Target: Seryl-tRNA Synthetase (SARS)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details

Binding Specificity: AA 46-518

Purpose: SerRS Antibody / Seryl-tRNA synthetase / SARS2

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids E46-S518) was used as the immunogen for the SerRS antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SerRS antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SerRS antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details

Target: Seryl-tRNA Synthetase (SARS)

Alternative Name: SerRS

Background: Seryl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the SARS2 gene. This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene.

UniProt: Q9NP81