AMH antibody (C-Term)

Catalog No. ABIN7875132

The Mouse Monoclonal anti-AMH antibody is suitable to detect AMH in samples from Human. It has been validated for IHC (p).

Quick Overview for AMH antibody (C-Term) (ABIN7875132)

Target: AMH (Anti-Mullerian Hormone (AMH))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This AMH antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: AMH-7354

Product Details anti-AMH Antibody

Binding Specificity: AA 460-560, C-Term

Purpose: Anti Mullerian Hormone Antibody / AMH

Purification: Protein A/G affinity

Immunogen: A recombinant fragment of the C-terminus of the human protein (within amino acids 460-560) was used as the immunogen for the Anti Mullerian Hormone antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Anti Mullerian Hormone antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Anti Mullerian Hormone antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for AMH

Target: AMH (Anti-Mullerian Hormone (AMH))

Alternative Name: Anti Mullerian Hormone

Background: The transforming growth factor beta (TGF beta) superfamily is composed of numerous growth and differentiation factors, including TGF beta1-3, Mullerian inhibiting substance (MIS), growth/differentiation factor (GDF) 1-9, bone morphogenic protein (BMP) 2-8, glial cell line-derived neurotrophic factor (GDNF), Inhibin Alpha, beta-A, beta-B and beta-C, Lefty and Nodal. Members of the TGF beta superfamily are involved in embryonic development and adult tissue homeostasis. The MIS glycoprotein is produced by the Sertoli cells of the testes. Fetal testes produce both MIS and testosterone, the presence of which result in male offspring. Absence of MIS and testosterone in a developing fetus results in the induction of Mullerian duct differentiation, and Wolffian duct development is not induced. Testosterone induces the differentiation of the Wolffian ducts whereas MIS causes regression of the Muellerian duct. MIS inhibits the growth of tumors derived from tissues of Mullerian duct origin. MIS can also inhibit the autophosphorylation of the EGF receptor in vitro. Defects in anti-Muellerian hormone are the cause of persistent Muellerian duct syndrome type I (PMDS-1). PMDS-1 is a form of male pseudo hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.

UniProt: P03971

Pathways: Negative Regulation of Hormone Secretion