PAS1C1 antibody (AA 48-349)

Catalog No. ABIN7875205

The Rabbit Polyclonal anti-PAS1C1 antibody (ABIN7875205) specifically detects PAS1C1 in WB, ELISA and FACS. The antibody is reactive with Human and Rat samples.

Quick Overview for PAS1C1 antibody (AA 48-349) (ABIN7875205)

Target: PAS1C1 (IFLTD1) (Intermediate Filament Tail Domain Containing 1 (IFLTD1))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAS1C1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-PAS1C1 Antibody

Binding Specificity: AA 48-349

Purpose: LMNTD1 Antibody / Lamin tail domain-containing protein 1

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human LMNTD1 recombinant protein (Position: Y48-E349) was used as the immunogen for the LMNTD1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the LMNTD1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the LMNTD1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PAS1C1

Target: PAS1C1 (IFLTD1) (Intermediate Filament Tail Domain Containing 1 (IFLTD1))

Alternative Name: LMNTD1

Background: LMNTD1 antibody detects Lamin tail domain-containing protein 1, a poorly characterized nuclear envelope-associated protein believed to play roles in chromatin organization, nuclear structure, and cell differentiation. LMNTD1 is part of the broader family of lamin-associated proteins that contribute to the mechanical stability and spatial arrangement of the nucleus. The LMNTD1 antibody is used in studies of nuclear architecture, gene expression control, and tissue-specific nuclear envelope composition.

LMNTD1 is encoded by the LMNTD1 gene located on human chromosome 8p21.3. The protein is approximately 63 kilodaltons and characterized by a conserved lamin tail domain that mediates binding to lamins A/C and chromatin-associated factors. LMNTD1 localizes to the inner nuclear membrane, where it may anchor chromatin regions and participate in gene silencing through lamina-associated domains (LADs).

The LMNTD1 antibody detects a 63 kilodalton band in western blot analysis and shows nuclear rim staining under confocal microscopy. Although its function remains incompletely defined, LMNTD1 is proposed to stabilize nuclear structure during differentiation and respond to mechanical stress transmitted through the cytoskeleton. Expression studies indicate enrichment in testis, brain, and embryonic tissues, suggesting developmental and reproductive roles.

Emerging data suggest LMNTD1 interacts with components of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex, potentially influencing nuclear positioning and signal transduction. Altered LMNTD1 expression has been observed in certain cancers and developmental disorders, where disrupted nuclear architecture correlates with genomic instability and transcriptional dysregulation.

By linking nuclear lamina integrity with chromatin organization, LMNTD1 contributes to structural and functional compartmentalization of the nucleus. NSJ Bioreagents provides a validated LMNTD1 antibody optimized for western blot, flow cytometry, and nuclear envelope studies, facilitating research into nuclear mechanics, gene silencing, and developmental regulation.

UniProt: Q8N9Z9